Spironolactone

4 important questions on Spironolactone

How may treatment with Spironolactone lead to increased potassium levels?

Spironolactone is a potassium-sparing diuretic with antagonistic effects on aldosterone, which leads to inhibited potassium excretion and sodium reabsorption, thereby resulting in increased potassium levels.

Why has Spironolactone a positive effect in patients with nephrotic syndrome?

Since Spironolactone is a diuretic, it stimulates water excretion, which is effective in patients with nephrotic sydrome that excrete proteins and therefore retent water.

Why should patients treated with Spirinolactone limit dietary intake of potassium?

The combination of increased dietary intake of potassium with increased potassium retention may lead to hyperkalaemia.
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Why is Spironolactone used for treatment of oedema?

Since Spirinolactone stimulates sodium and water excretion by potassium retention, the accumulation of fluid causing oedema may be resolved.

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