Valsartan
3 important questions on Valsartan
What is the working mechanism of Valsartan?
Valsartan has an antagonistic effect on angiotensin II, which inhibits binding to the AT-1receptor, thereby preventing the onset of vasocontriction and thus leading to reduced blood pressure.
What is the formation process of angiotensin II?
Angiotensin I is produced by renin and angiotensinogen, which is then transformed into angiotensin II in a reaction catalyzed by angiotensin-converting enzyme.
How will Valsartan be distributed throughout the body if its Vd=17L?
Valsartan will probably only distribute over the blood and extracellular tissue fluid, which is effective in its function of acting on receptors in the blood vessels.
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