The downward slope - Cardiac innervation - Parasympathetic nervous system
5 important questions on The downward slope - Cardiac innervation - Parasympathetic nervous system
How does the parasympathetic nervous system affect the heart?
What is the mechanism for parasympathetic innervation of the heart?
The M2 receptors are negatively coupled to adenylate cyclase- reducing the formation of cAMP- affecting the conductance of ca2+.
Additionally, the M2 receptors open the K+ channels- increasing the membrane permeability to K+.
- the reduction in the influx of Ca2+ and the increase in the influx of K+ results in hyperpolarisation of the cell, meaning that it will take longer for the threshold to be reached (-65mV). this means that heart rate slows down.
Which part of the heart are innervated by the parasympathetic nervous system?
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What are the consequences of vagal stimulation?
Strong vagal stimulation can block transmission to the AV node- consequently, the perkunji fibres will stimulate their own signal that will cause contraction of the ventricles.
What is ventricular escape?
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