The Stabbing - Actions of the autonomic nervous system - Response to trauma

11 important questions on The Stabbing - Actions of the autonomic nervous system - Response to trauma

What are the physiological changes associated with the flight or fight response?

- acceleration of the heart rate
- acceleration in breathing rate
- inhibition of salivary glands
- general effect on sphincters of the body
- constriction of blood vessels
- dilation of the blood vessels that supply the muscles
- increase production of glucose
- increase metabolism of fats, proteins, carbohydrates for energy
- dilation of the pupils
- relaxation of the bladder
- inhibition of erection

What are some of the endocrine responses?

Increases secretion of the pituitary hormones= affects the secretion of secondary hormones from the target organs.

Fat metabolism increases = increase in cortisol, corticotrophins and growth hormone
Protein metabolism increases = cortisol and corticotrophins
Carbs metabolism increases = cortisol and corticotrophins

What are the sympathoadrenal responses?

increase secretion of adrenaline from the adrenal medulla. increase secretion of noradrenaline from the postganglionic neurones.
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What is the hypothalmic-pituitary adrenal axis response?

Anterior
increase in secretion: cortisol, corticotrophins, growth hormone, prolactin
decrease in secretion: TSH, LH and FSH

Posterior
increase secretion of ADH

What is the immunological response?

increase in cytokine production: IL-1, TNF-alpha and IL-6. These increase the recruitment of macrophages and the inflammatory response.

What is the relationship between IL-6 and the acute phase response?

levels of IL-6 are initially low, but increase following a trauma. It is believed that IL-6 is responsible for the secretion of acute phase proteins in response to inflammation.

CRP-liver
ESR
Fibrinogen
Ferritin

What is the role of corticotrophins?

Stimulate the secretion of glucocorticoids from the adrenal glands.
Glucocorticoid is the main hormone responsible for the resistant phase.

What is the role GH?

Regulates growth and metabolism. Inhibits the uptake of glucose by body cells so that it is available for neurones.
Prevents proteins breakdown.
Stimulates protein synthasis.

What is the role of thyroid hormone?

Stimulates O2 consumption by metabolically active cells.
Increases carbs absorption from the gut.
Stimulates the peripheral and central nervous system

What is the role of renin?

Increases the synthesis of angiotensin II. Allows Na+ and water resorption. Maintains a high blood volume

What are the effects of trauma on breathing?

C4 or higher: diaphragm
T1-T11: intercostal muscles
T7-T12: abdominal muscles
Cervical region: need support breathing

Weak breathing means that bacteria cannot be expelled out of the body appropriately and so risk of bacterial infection increases

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