Structure of the Immune System - Secondary lymphoid organs - Spleen
5 important questions on Structure of the Immune System - Secondary lymphoid organs - Spleen
What does the white pulp consist of?
- PeriArteriolar Lymphatic Sheats (PALS, sheath of Tcells)
- B follicles attached to PALS
- Marginal zone with a lot of APC macrophages
What does the B follicle contain?
What is the size of the Germinal Centre related to?
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What 3 different macrophages are present in the spleen of a mouse and what are they for?
- Marginal zone macrophages, express unique set of PRR, crucial for clearance of viruses and bacteria
- Marginal zone metallophoilc macrophages, without known function
- Red pulp macrophages, remove aged red blood cells
What 2 types of dendritic cells are found in the white pulp and what are they for?
- follicular dendritic cell (FDC) in the B cell follicle
- Interdigitating dendritic cells (IDC) in the T cell area (PALS)
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