Structure of the Immune System - Secondary lymphoid organs - Spleen

5 important questions on Structure of the Immune System - Secondary lymphoid organs - Spleen

What does the white pulp consist of?

  • PeriArteriolar Lymphatic Sheats (PALS, sheath of Tcells)
  • B follicles attached to PALS
  • Marginal zone with a lot of APC macrophages

What does the B follicle contain?

B cells (memory and differentiating) in the Germinal Centre (GC)

What is the size of the Germinal Centre related to?

To the antigen-load and immune reaction of the animal
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What 3 different macrophages are present in the spleen of a mouse and what are they for?

  • Marginal zone macrophages, express unique set of PRR, crucial for clearance of viruses and bacteria
  • Marginal zone metallophoilc macrophages, without known function
  • Red pulp macrophages, remove aged red blood cells

What 2 types of dendritic cells are found in the white pulp and what are they for?

  • follicular dendritic cell (FDC) in the B cell follicle
  • Interdigitating dendritic cells (IDC) in the T cell area (PALS)
they are important for homing of T and B cells, initiation of adaptive immune response and maintaining immunological memory for years

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