Duchenne muscular distrophy genetics and molecular biology
11 important questions on Duchenne muscular distrophy genetics and molecular biology
When are genes transmitted to the next generation independent?
What happens when genes are on the same chromosome but far apart?
How does linkage mapping with RFPLs work?
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What are the major structural changes on the chromosome?
How can some women get Duchenne?
- no X chromosome from the father(syndrome of turner).
- X-chromosome inactivation
- One X chromosome is damaged and unable to mask the non-damaged X chromosome.
How can you map the DMD gene?
By comparing the deletions on the X chromosomes of males with DMD or an other X linked disease.
How does Fluorescence in situ hybridisation work?
How does X-chromosome inactivation work?
Some times the healthy X-chromosome is inactivated, which in the case of DMD will give rise to Duchenne in females. There is a difference in DNA methylation.
What makes the Dystrophin gene special?
How is dystrophin regulated?
- 2 poly (A)- addition sites
- alternative slicig
How can you repair a defective gene with a small RNA molecule?
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