Sweetness and sweeteners - Positive allosteric modulators
5 important questions on Sweetness and sweeteners - Positive allosteric modulators
How can the bitter off-tastes or lingering of sweeteners be solved?
- Combining sweeteners, so that their threshold does not exceed the negative effect
- Positive allosteric modulators (PAMs)
How can the bitter off-tastes or lingering of sweeteners be solved?
- Combining sweeteners, so that their threshold does not exceed the negative effect
- Positive allosteric modulators (PAMs)
Where do PAMs bind?
- Sweetener binds deep in the pocket of the VFTD close to the hinge region of the receptor domain
- PAMs bind further away from the hinge region, stabilising closed conformation
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Can PAMs work in the absence of the sweetener?
What are the most potent PAMs?
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