Sweetness and sweeteners - Blocking sweet taste
4 important questions on Sweetness and sweeteners - Blocking sweet taste
Which receptor is involved in the lactisole blocking?
Does lactisole block the receptor activity completely?
Which domain of the T1R3 receptor is involved in the lactisole binding?
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How does lactisole block the sweet response?
- One of the histidine residues of importance is positively charged at physiological pH and forms a salt bridge with the negatively charged carboxyl group of lactisole.
- One of the alanine residues is assumed to have hydrophobic interaction with the methoxy-group.
- Binding of lactisole to the transmembrane domain locks the receptor in the inactive ground state. The receptor cannot change its conformation for further signal transduction.
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