Taste perception - Inter-individual variation in perception of bitter, sweet and umami

4 important questions on Taste perception - Inter-individual variation in perception of bitter, sweet and umami

Which compound is important for research towards variation in sensitivity towards bitterness among people.

Phentylthiocarbamide (PTC)

What causes the inter-individual variation in sensing tastants?

Differences in the amino acid sequence of the receptor proteins. Often, a change in one to three amino acids in the receptor proteins, at key positions for ligand-binding, cause the different sensitivity to tastants.

Which mutations can occur in the genes encoding the receptor proteins?

Single Nucleotide Polymorphisms (SNPs)
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How is a combination of three nucleotides called?

A codon, it corresponds to one amino acid.

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