Sweetness and sweeteners - Binding sites for sweet molecules on T1R2/T1R
3 important questions on Sweetness and sweeteners - Binding sites for sweet molecules on T1R2/T1R
What is the difference between the VFTDs of T1R2 and T1R3?
- T1R2: small and narrow binding pocket --> can accommodate small molecules
- T1R3: large and broad binding pocket --> can accommodate small and larger molecules
Where do sweet proteins (large) and small molecules bind? And what happens to the VFTD conformation?
- Sweet proteins (large) --> outside of the T1R3 VFTD --> interact with the outer parts of the lobes of the VFTD of T1R3 --> semi-closed
- Small molecules --> deeply in the VFTD close to the hinge region of either T1R2 or T1R3 --> closed
Where does lactisol (sweet blocker) bind in T1R3?
In the transmembrane domain
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