Summary: Chromosome Instability And Cancer
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Read the summary and the most important questions on Chromosome Instability and Cancer
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1 Day 1
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1.1 Introduction Chromosomal Instability
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High rate of chromosome segregation errors occur in?
M phase -
Various flavors of segregation errors
- Chromatin bridge
- Acentric chromosome
- Lagging chromosome
- Misaligned chromosome
- Chromatin bridge
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Problems in prior S/G2 phase causes?
- Chromatin bridge
- Acentric chromosome
- Chromatin bridge
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1.2 A guided tour through Mitosis
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The purpose of M phase
The equal distribution of the duplicated chromosomes (and centrosomes) over two new daughter cells -
Dramatic cellular (DNA and cytoskeletal) changes associated with mitosis:
- DNA condensation
- Mitotic spindle assembly
- Nuclear envelope breakdown
- Formation of the outer-kinetochore
- DNA condensation
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The requirement for correct segregation?
Chromosome bi-orientation -
Attachment errors occur in (pro)metaphase and can result in?
Chromosome mis-segregation in anaphase -
Aurora B dependent phosphorylation of the KMN network reduces its?
Microtubule binding affinity -
The Mitotic Checkpoint (aka the Spindle Assembly Checkpoint)
Prevents anaphase onset until all sister-chromatids are connected to the mitotic spindle -
Initiating Anaphase & Mitotic Exit
- Separase active
- Cdk1 inactive
- Separase active
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