Safeguarding chromosome structure: Double strand break repair
5 important questions on Safeguarding chromosome structure: Double strand break repair
How do aneuploidy and chromosome structures contribute to tumorigenesis?
- Intratumor heterogeneity
- Gain of oncogenes
- Loss of tumor suppressor genes
How do these abnormal chromosome structures (acentric/dicentric) form?
What are the main exogenous causes of DSBs?
- Ionizing radiation
- Gamma rays
- X-ray
- Anti-cancer chemotherapeutics
- DNA alkylating agents
- DNA crosslinking agents
- Topoisomerase inhibitors
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What are the main endogenous causes of DSBs?
- Metabolites (ROS, alkylating agents)
- V(D)J recombination (B and T-cells)
- Transcription (RNA:DNA hybrids)
- Replication stress
- Telomere dysfunction
How do DSBs normally get repaired?
- Canonical DSB repair pathways
- Non-Homologous End Joining (c-NHEJ)
- Homologous Recombination (HR)
- Alternative DSB repair pathways
- Single Strand Annealing (SSA)
- Alternative End-Joining (alt-EJ)
- Microhomology-mediated template switching
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