Cell-Based Therapies for cardiac repair

4 important questions on Cell-Based Therapies for cardiac repair

Delivery cell choices and challenges?

Intravenous, intracoronair, Intramyocardial

3% cells stay in heart. Venous coronary system -> Stuck in capillaries lung. Better = Patches of 3D-printing on heart, but more invasive

Safety, cell retention, spatial distribution.

Challenges Survival and proliferation?

Ischaemic invironment, inflammation, immune, fibrosis, formation blood vessels

Less immune reaction. First short injection. T-memory cells not yet produced

Blocking apoptosis/necrosis no effect

Challenges Electromechanical integration?

Differentiation, mature myocyt, electrical integration, mechanical coupling
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Challenges stability & safety?

Long term engraftment, arrhythmogenicity

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