Practical and ethical considerations (FitLab)
3 important questions on Practical and ethical considerations (FitLab)
What are the rodent models for physical activity?
- Forced exercise model
- treadmill, swim
- can put a lot of stress on animals --> does not replicate voluntary motivation to be active in humans
- Voluntary exercise model
- wheel, wall
- can mimic aspects of the human aerobic exercise training
What are the advantages and disadvantages of human studies?
Advantages
Disadvantages:
- data is representative from human/real world
- usage of interview, questionnaire, blood samples, organoids
Disadvantages:
- ethical approval
- privacy limitations
- challenging to recruit participants
- challenging in control groups
- limitation in technical options
What are the advantages and disadvantages of basal (animal) studies?
Advantages:
Advantages:
- genetic control
- collection blood, organs
- moment of tissue collection can be determined by researcher
- use of invasive techniques
- less challenging for control groups
Advantages:
- non-human data --> need to be translated
- ethical approval
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