Lecture: Schizophrenia
9 important questions on Lecture: Schizophrenia
Explain what positive symptoms are and give 2 examples.
These are psychotic episodes (desilusions and hallucinations)
Psychotic episodes can also be a symptom of other psychiatric diseases such as:
- Bipolar disorder
- Major depressive disorder
Explain hallucinations. Which kind of hallucinations are the most common?
- Most common: auditory (harsh voices giving negative comments/orders)
- But may occur in any sensory modality: visual, tactile, gustatory, olfactory (smell of gas, rotting meat).
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Explain what negative symptoms of schizophrenia are and give 4 examples.
- Blunted affect: restrictions in rage and intensity of emotional expression (feeling empty, recalls few emotional experiences; little facial expression).
- Dysfunction of motivation: reduced motivation persistence, passivity, reduced ability to undertake and complete everyday tasks; may have poor personal hygiene.
- Anhedonia: dysfunction of capacity for pleasure; reduce ability to experience pleasure; decreased interest in previous hobbies.
- Asociality: reduced social drive and interaction. Little sexual interest, few friends, little interest in spending time with friends.
Which drug do you know that could elicit psychosis?
How do first antipsychotics work?
Draw the mesolimbic dopamine pathway. Mesolimbic overactivity leads to:
'too much DA in ventral striatium'.
Draw the mesocortical dopamine pathway. Underactivity leads to?
- Too little DA in PFC.
Integrated dopamine hypothesis of schizophrenia attempts to explain all symptoms of schizophrenia by
- With relative preservation of functioning of nigrostriatal and tuberoinfundibular pathways.
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