Lecture: postnatal brain development - Parkinson's

8 important questions on Lecture: postnatal brain development - Parkinson's

Which parts of the brian are involved in parkinsons'?

  • Pyramidal system (cerebral cortex, brainstem, spinal cord)
  • Peripheral nerve system
  • Muscle
  • Cerebellum
  • Extrapyramidal system (basal ganglia)

Explain from slowness of movement to fast movement. athetosis, ballismus, bradykinesia, chorea, dystonia, hyperkinesia, myoclonus, rigidity, tics, tremor (rhythmic movement of a limb)

Slowness of movement → fast movement:
bradykinesia, hyperkinesia, rigidity, dystonia, athetosis, chorea, ballismus, tics, myoclonus, tremor (rhythmic movement of a limb).
In parkinsons they have hypokinesia and hyperkinesia

Which cues are present years before the diagnosis?

  • shoulder pain.
  • obstipation
  • not able to smell
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For the diagnosis  you need ..., otherwise you dont have it. What symptoms play a major role too?

Bradykinesia (slowness of movement)

Rigidity and resting tremor.

Parkinsonism. Differential diagnosis:
give 3 .

Hint. The last one includes 4 types.

  • Drug induced parkinsonism
  • Vascular parkinsonism. Legs are more affected.
  • Atypical parkinsonism
- Multiple system atrophy (MSA)
- Progressive supranuclear palsy (PSP)
- Dementia with Lewy Bodies (DLB)
- Cortical basal degeneration (CBD)

Which 3 systems are involved in PD?

Noradrenaline, serotonin and acetylcholine.

Explain the 3 domaminergic treatments for motor symptoms

  • Levodopa
  • Dopamine agonist
  • MAO B inhibitor

What are the 3 motor complications?

  • Freezing (walks and then stops)
  • Festination (walking on one place)
  • Falls

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