Mechanisms - Denervation

3 important questions on Mechanisms - Denervation

What happens to the innervation in aged muscles?

  • the number of motor units decrease relative to the young
  • the number of motor neurons decrease in the spinal cord
  • the remaining motor units increase in size

To what characteristics of saropenia is denervation related?

  • atrophy of type 2 fibers
  • decrease in specific tension
  • clustering of muscle fibers

What factor, that is reduced in aged muscle, regulates reinnervation?

Ciliary neurotrophic factor (CNTF)

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