The genetics of cancer - cancer predisposition (aanleg)
6 important questions on The genetics of cancer - cancer predisposition (aanleg)
Where are twin studeis used for...?
What is a cancer predisposition gene?
- most of them are oncogenes, byt can be tumor suppressors
Indications for cancer predisposition?
- Family history of cancer
- early age at diagnosis
- multiple tumors
- shared cancer-related phenotypes
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De type cancer predisposition genes? (3)
- Genes involved in cell cycle regulation
- genes directly involved in tumorigenic process (cancer-related pathways)
- genes that affect genomic integrity
- DNA repair
- mitotic checkpoints
Why are recessive syndromes less frequent, but often time more server?
- Recessive disease mutations are much more common than those that are harmful even in a single copy, because such "dominant" mutations are more easily eliminated by natural selection.
- disease-causing recessive alleles remian in populations because healthy hetrozygotes pass them to future generations
How do we recognize patients with cancer? (3)
- Clinical characteristics
- gene mutation
- tumor characteristics
- subtype specification
- second hit mutations
- mutational signatures
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
