Cardiovascular diseases

9 important questions on Cardiovascular diseases

WHich cell layer around the blood vessel is damaged in atherosclerosis?

The endothelium, most inner layer

Why does a lesioned endothelial layer vasoconstrict?

To prevent blood loss by enlarging the lesion.

Why is the function of endothelium reversed in a damaged setting?

To the prevent acute blood loss.
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What can be the clincal difference between a thin fibrous cap and a thick fibrous cap?

Thin cap = more chance of an infarction
Thick cap = angina pectoris

What does a statin do?

Reduce both cholesterol AND CRP

Why do conventional risk factors for Cardiovascular diseases not decrease that much in RA?

Because it probably has a large portion of inflammation in it.

What can be a hypothesis about the lower intermedia thickness, but not the higher cardiovascular risk in diabetes compared to Atherosclerosis?

The influence of inflammation is much higher in the atherosclerotic population, accounting for te higher CVD risk.

How to reduce the risk for CVD in RA?

Keep inflammation down.

What is the main effect of adiposity on atherosclerosis?

Adiposity increases the amount of FFA and cholesterol that can be oxidized and cause foam cell formation.

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