Transcription regulation

7 important questions on Transcription regulation

Where depends gene activation and supression on?

  • Protein-DNA interactions
  • protein - protein interactions
  • DNA - DNA interactions
  • nuclear structure

What is the specialization of RNA polymerase III?

Small stable RNAs

What is the specialization of RNA II?

Protein coding genes and several non-coding genes
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Where is RNAP I located?

Nucleoli

Function distal promoter

Promotes assemble of the promoter that binds at core promotor

What are the functions of DNA binding transcription factors?

  • Select which genes to transcribe or to silence
  • Facilitate and stimulate the assembly of the transcription initiation complex together with RNA polymerase at the start site of transcription
  • Recruit nucleosome histone-modifying enzymes.

Why are histone tails important?

Histone tails extend beyond the nucleosome, and are sites of (mostly) reversible post-translational modifications. This is essential for gene activity/inactivity

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