Summary: Experimental Immunology | VU
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1 Innate immunesystem
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What is the first line of defense?
Physical, chemical and microbiological barriers.
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What is the second line of defense?
Innate immunesystem.
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What are components of the innate immunesystem?
Phagocytosis, complement, interferon, inflammation, fever.
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What is the third line of defense?
Adaptive immunesystem.
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What are components of the adaptive immunesystem?
Lymphocytes, antibodies.
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What is the aim of the innate immune system?
Recognition of the pathogen and attraction of effector cells that take up and destroy the pathogen. -
What are the three functions of the complement system?
1. Formation of the membrane attack complex(MAC) --> bacterial lysis. 2. Initiation of the imflammatory response. 3. Opsonization and phagocytosis.
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The cellular innate immune respons is mediated by...?
Pattern recognition receptors (PPRs).
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What do PRRs recognize?
Pathogen Associated Molecular Patterns (PAMPs), for example: DNA/RNA, Cell wall components such as lipids, sugars, proteins. They are molecular signatures of invading pathogens.
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Name the 4 different classes of PRRs.
1. C-type lectine receptor. 2. Toll-like receptor. 3. NOD-like receptor. 4. Retinoic-acid-inducable gene I like receptor.
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