Innate immunesystem

6 important questions on Innate immunesystem

NOD-like receptors are responsible for the producton of...

pro-inflammatory cytokines (NF-κB) and IL-1β (inflammasome)

What is needed for the production of IL-1B?

Two signals. 1. transcription of Pro-IL-1 beta and Pro-IL-18. 2. indirect activation of the inflammasome, such as ion or membrane perturbations, reactive oxygen species (ROS), or extracellular ATP.

What do c-type lectin receptors recognize?

 

Specific sugar patterns and it's calcium dependent. They modulate the signaling action of other PRRs.

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What determines the innate immuneresponse?

Combination of PRRs which are triggered.

Describe the M1 macrophage.

Under the influence of IFNY and LPS, a monocyte becomse a M1 macrophage. It's called the classical activation. It is for:
• Anti-microbial activity
• Tumor resistance • Induction T helper 1 responses • Tissue destruction 

Describe de M2 macrophage.

Under the influence of for example IL-4 and IL-13, a monocyte becomes an M2 macrophage. It's called the alternative activation. It's for:
• Angiogenesis
• Tumor promotion • Immunoregulation • Tissue repair

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