Dyslipidemia in RA

4 important questions on Dyslipidemia in RA

What is the lipid pattern in RA patients?

  • High triglycerides
  • Low HDL, LDL and total cholesterol

What is ESR a measure for and what does it tell clinicians?

ESR is the erythrocyte sedimentation rate when performing a blood test and a low ESR is correlated to higher HDL and cholesterol.

What is said about HDL cholesterol and vascular events?

Low HDL is highly correlated with the risk of vascular events.
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What are the underlying mechanisms of the lipid pattern seen in RA?

The elevation of cytokines in RA may increase the lipolysis of adipose tissue, leading to an increase in FFA release. It may also increase the FFA release and triglyceride release from the liver and it reduces the activity of the triglyceride catabolic enzyme in endothelial cells.

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