Insulin Resistance

4 important questions on Insulin Resistance

How do inflammatory cytokines influence the insulin sensitivity of cells?

TNFa impedes insulin-mediated glucose and stimulates adipocyte lipolysis which enhances metabolic cycling of FFA.

What is the effect of TNF-a on insulin sensitivity?

  • impedes glucose uptake in skeletal muscle cells
  • increases the release of FFA from adipocytes
  • stimulate adipocyte lipolysis

What happens to insulin sensitivity in RA?

Is seems to be related to basal hyperinsulinemia and insulin resistance.
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How was the relationship between insulin resistance and inflammation discovered?

RA patients were treated with steroids and remarkably their insulin sensitivity improved, while in healthy subjects, steroids increase insulin resistance.

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