Immunopathology of allergy - The allergic reaction
5 important questions on Immunopathology of allergy - The allergic reaction
What happens when an allergen intrudes the body?
When can you call a person sensitised?
Allergic sensitisation can last for many months to years, but does not necessarily lead to an immediate clinical allergy response. T/F
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What is the 'challenge phase'?
What happens in the 'challenge phase'?
- Subsequent exposure to the same allergen
- Binding of the allergen protein to the mast cell-bound IgE
- Multiple binding site on the protein, more IgE binds and cross-linked
- Cross-link gives intracellular signal in the mast cell
- Mast cell degranulates and release inflammatory mediators stored inside
- Histamine released, causes vasodilatation (blood vessels wider) and triggering of nerve cells --> swollen eyes, itching sensations
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