Immunopathology of allergy - The underlying mechanism in allergy

9 important questions on Immunopathology of allergy - The underlying mechanism in allergy

Which cytokines are essential to induce class switching to IgE in B cells?

IL-4 and IL-13

In which diseases is the epithelial barrier leaky?

  • Asthma
  • Chronic rhinosinusitis
  • Atopic dermatitis

Which cells produce pro-inflammatory cytokines and chemokines?

  • Epithelial cells
  • Dendritic cells
  • Innate lymphoid cells
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The immunologic basis of allergic diseases is observed in 2 phases:

  1. Sensitisation phase
  2. Effector phase

Which cytokines contribute to type 2 responses of T cells?

IL-25, IL-31, IL33 and TSLP

Which 2 PRR exist?

  • Soluble (collectins)
  • Cellular (TLR)

What do soluble PRRs do?

They recognise the carbohydrate moieties of microbes and can activate the complement cascade, initiating inflammatory responses.

TLRs are best known for binding to products of microbes and viruses, allergens can also interact with TLRs. T/F

True

What do IgE molecules consist of?

A 12% carbohydrate content with oligosaccharides asparagine-linked at six places all int he first 3 or 4 constant region domains. They have a limited segmental flexibility.

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