Celiac disease - an immunological perspective - Immunopathology of CD

3 important questions on Celiac disease - an immunological perspective - Immunopathology of CD

Which amino acid is abundantly present in gluten derived peptides?

Proline

Which 2 amidations occur in with celiac disease?

  1. Enzyme mediated: TTG changes (+)glutamine to (-)glutamic acids residues
  2. Acid-induced: in the stomach within 3h treatment of gliadin with gastric juice

The genes associated with celiac disease could be distributed in 4 categories

  1. Polarity and epithelial cell functionality
  2. Intestinal smooth muscles
  3. Growth and energy homeostasis
  4. Innate and adaptive immune response

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