Methods and strategies of research

7 important questions on Methods and strategies of research

What is experimental ablation/lesion studies?

Destroying a bit of brain tissue and observe the behavorial consequences.

What are excitotoxic lesions?

Overexcited neurons due to the injection of an exctitatory amino acid. This is a more selective method.

What is a sham lesion?

A placebo procedure, in which the operation is done the same way as for the real lesions. Only there is no damage to the tissue, this way parameters are almost exactly the same.
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What are methods of recording neural activity?

Microelectrodes
Macroelectrodes
Magnetoencephalography

How do you record the brains metabolic and synaptic activity?

autoradiography
Fos(protein)
Functional imaging
Positron emission tomography(PET)

What are methods of stimulating neural activity?

Electrical
Chemical
optogenetic
Transcranial magnetic stumulation

What are some genetic methods?

Twin studies
Adoption studies
Genomic studies
Targeted mutations
Antisense Oligonucleotides

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