The tissue level of organization - Epithelial tissue covers body surfaces, lines internal surfaces, and serves other essential functions

21 important questions on The tissue level of organization - Epithelial tissue covers body surfaces, lines internal surfaces, and serves other essential functions


What are the three specializations of epithelial cells?

  1. The movement of fluids over the epithelial surface, providing protection and lubrication.
  2. The movement of fluids through the epithelium, to control permeability.
  3. The production of secretions that provide physical protection or act as chemical messengers.


A specialized epithelial cell is often divided into two functional regions. What are these regions and what does it mean?

This means that the epithelial cell has a strong polarity.
The two regions are the apical surface and the baso-lateral surfaces.
The apical surface is where the cell is exposed to an internal of external environment.
The baso-lateral surface includes both the base (basal surface), where the cell attaches to underlying epithelial cells or deeper tissues, and the sides (lateral surfaces), where the cell contacts its neighbors.


Where are microvilli especially abundant?

Microvilli are especially abundant on epithelial surfaces where absorption and secretion take place, such as along portions of the digestive system and kidneys.
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What are motile cilia? What is their function?

Cilia are fairly long, slender extensions of the plasma membrane.
Motile cilia are important because they 'beat' rhythmically to move fluids or secretions across the cell surface.


What are the three factors that help maintain the physical integrity of an epithelium?

  1. Intercellular connections
  2. Attachment to the basement membrane
  3. Epithelial maintenance and repair.

What are cell adhesion molecules (CAMs)?

CAMs are transmembrane proteins that interconnect large areas of opposing plasma membranes. CAMs bind to each other and to extracellular materials.

What are cell junctions?

Cell junctions are specialized areas of the plasma membrane that attach a cell to another cell or to extracellular material.

What are the three most common types of cell junctions?

  • Gap junctions
  • Tight junctions
  • Desmosomes

What is a gap junction?

At a gap junction, two cells are held together by two embedded interlocking transmembrane proteins called connexons. Two alligned connexons form a narrow passageway that lets small molecules and ions pass from cell to cell. This is necessary for rapid intercellular communication.

What is a tight junction?

A tight junction is formed by the fusion of the outer layers of two plasma membranes. Tight junctions prevent the diffusion of fluids and solutes between the cells. A continuous adhesion belt is tied to the microfilaments of the terminal web.

What is the function of the adhesion belt in a tight junction?

The adhesion belt is a forms a continuous band that encircles cells and binds them to their neighbors.

What is a desmosome?

A desmosome is where CAMs and proteoglycans link the opposing plasma membranes. Desmosomes are very strong and can resist stretching and twisting.

What are the two types of desmosomes?

  • Spot desmosome
  • Hemidesmosome


What is a spot desmosome?

Spot desmosomes are small discs connected to bands of intermediate filaments. The intermediate filaments stabilize the shape of the cell.

What is a hemidesmosome?

Hemidesmosomes resemble half of a spot desmosome. Rather than attaching one cell to another, a hemidesmosome attaches a cell to extracellular filaments in the basement membrane. This attachment helps stabilize the position of the epithelial cell and anchors it to underlying tissues.

What two layers does the basal membrane consist of?

Basal lamina and reticular lamina.
Basal lamina is closest to the epithelium. It functions as a selective filter and it restricts the movement of proteins and other large molecules from the underlying connective tissue into the epithilium.
The reticular lamina is the deeper portion of the basement membrane. It consists mostly of reticular fibers and ground substance. This layer gives the basement membrane its strength. The reticular lamina also acts as a filter that determines what substances can diffuse between the adjacent tissues and the epithelium.

Identify four essential functions of epithelial cells.

  • Physical protection
  • Control permeability
  • Provide sensation
  • Produce specialized secretions

List five important characteristics of epithelial tissue.

  • Polarity
  • Cellularity
  • Attachment
  • Avascularity
  • Regeneration

What is the probable function of an epithelium whose cells bear microvilli?

An epithelium whose cells have microvilli is probably involved in absorption or secretion. The microvilli greatly increase the cellular surface area available for these processes.

Identify the various types of epithelial cell junctions.

  • Tight junctions
  • Gap junction
  • Spotdesmosomes
  • Hemidesmosomes


What is the functional significance of gap junctions?

Gap junctions allow small molecules and ions to pass from cell to cell. When connecting epithelial cells, they help coordinate such functions as the beating of cilia. In cardiac and smooth muscle tissues, they are essential for coordinating muscle cell contractions.

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