Blood - The process of blood clotting, or hemostasis, stops blood loss - The Platelet plase
4 important questions on Blood - The process of blood clotting, or hemostasis, stops blood loss - The Platelet plase
What is the start of the platelet phase?
How does a platelet plug form?
What compounds to platelets release upon activation
- ADP (for aggregation and more secretion)
- Thromboxane A2 & serotonin; for vascular spasms
- Clotting factors; for blood clotting
- Platelet-derived growth factor (PDGF); promoting vessel repair
- Calcium ions; for further aggregation and clotting
Form positive feedback looop inducing a platelet plug
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What limits the formation of a platelet plug?
- Prostacyclin; inhibits platelet aggregation and released by endothelial cells
- Inhibitory compounds from WBCs
- Plasma enzymes; break down ADP near plug
- Development of blood clot; isolates plug from circulation
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