Blood - Red blood cells, formed by erythropoiesis, contain hemoglobin that transports respiratory gases - RBC Formation & Turnover

5 important questions on Blood - Red blood cells, formed by erythropoiesis, contain hemoglobin that transports respiratory gases - RBC Formation & Turnover

Describe the precursors of RBCs

Hemocytoblasts/hematopoietic stem cells (HSCs) divide producing myeloid stem cells (produce RBCs and some WBCs) and lymphoid stem cells (WBCs; lymphocytes).

What are the developmental stages of RBCs

Day 1 -> Differentiation into proerythroblasts
Day 2/3 -> Erythroblast stages; Basophilic ->  polychromatophilic
Day 4 -> Normablast; it sheds its nucleus to become (on day 5) a reticulocyte.
Day 5-7 -> Hemoglobin synthesis; then mature RBC enters bloodstream

What is erythropoietin? When is it released?

Stimulates erythropoiesis, appears under hypoxic (hypoxia) conditions; peripheral tissues have low oxygen concentrations.
Released during anemia, decrease in blood flow to kidneys, oxygen content in air decreases and damage to respiratory surfaces of lungs.
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What are the effects of erythropoietin?

Stimulation of cell divsion of erythroblasts and stem cells
Speeds up maturation of RBCs by accelerating Hb synthesis

What are the role of macrophages in recycling of RBCs?

Phagocytes engluf RBCs and remove Hb molecules from hemolyzed (ruptured) RBCs.  These will not remain intact outside RBCs

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