Summary: Fysiologie Spier/zenuw
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1 Fysiologie Spier/Zenuw
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Intracellular Fluid (ICF)
inside cells/intracellular compartment -
Extracellular Fluid (ECF)
outside/extracellular compartment -
Blood Volume definition + type cells
total volume of intravascular compartment
cells: erythrocytes, leukocytes, platelets -
Two ICF compartments
1. Dense connective tissue (cartilage, bones)
2. Bone matrix -
Difference between Plasma Fluid & Interstitial due to..
IF has no plasma proteins (can't cross capillary walls), affecting solute distribution due to volume occupation and charge -
Effect Protein Charge
plasma proteins = net negative charge -> retain cations in plasma
[cation] in interstitium is <5%
[anion] in interstitium is >5% -
Electrochemical Potential (deltaE)
1. chemical potential
2. voltage difference of charged solutes -
Integral Membrane Proteins (Function)
passive moment through intrinsic membrane proteins as most ions & hydrophilic solutes partition poorly in lipid bilayer -
Membrane Protein Pore
= always open
e.g. aquaporin H20 channels, perforin released by lymphocytes -
Membrane Protein Channel
= alternately open/closed with barrier/gate
e.g. virtually all ion channels
opening/closing = "gating"
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