Principles of toxicology

6 important questions on Principles of toxicology

What is the difference between intra- en interspecies?

intraspecies = thsis is between individuals due to genetic polymorphisme, age, nutrition and lifestysle, illnesses and gender
interspecies = body size: weight and surface area, small animals have a relatively large surface area which means they have dermal uptake and active metabolism. Different species also have different physiology. It's also possible that the toxic metabolism may vary.

What mean the next therms: LD50, NOAEL, LOAEL?

LD50 = lethal dose for 50% of the population
NOAEL = highest data point at which there was not an observed toxic or adverse effect
LOAEL = lowest data point at which there was an observed toxic or adverse effect

What is a toxic receptor?

receptor which is toxicated, it may cause the inhibiting or blocking of a function. But can also excessively stimulate functions.
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What is acute or chronic toxicity?

acute is where you get the high doses of the toxic within a short period of time. Chronic is where you get a low doses of the toxic within a longer period of time

What is primary lesion?

series of processes starting with a reaction at a molecular level 

What is haber's rule?

The effect of irritant gasses depends on the product of concentration and the dration of exposure

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