T10: Liver toxicity
9 important questions on T10: Liver toxicity
What is a fatty liver (steatosis)
What are causes of a fatty liver?
- oversupply of fatty acids
- Interference with triglyceride cycle
- Increased fatty acid synthesis/esterification
- decrease fatty acid oxidation
- Decreased apoprotein synthesis
- Decreased synthesis/secretion of VLDL
What are chemicals that cause liver toxicity?
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What is Hepatocyte death: necrosis & apoptosis
The function of the tissue is gone when the cells died.
zone 3 is most at risk here
Which types of effect represent adverse effects of chemicals on the liver?
-cholestasis
Toxic effects of chemicals on the liver?
Liver damage caused by aflatoxin
-aflatoxin requires bioctivation before it can can exert its adverse effect on the liver.
What is a liver tumor?
What chemicals can result in liver cancer?
Androgens
vinylchloride
arsenic
thorium dioxide
unsaturated pyrrolyzidine alkaloids (PAs)
alkenylbenzenes
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