Gene mutation and DNA repair - DNA repair
3 important questions on Gene mutation and DNA repair - DNA repair
What is the general proces for DNA repair?
- An irregularity is detected by one or more proteins;
- The abnormal DNA is removed by the action of DNA repair enzymes;
- Normal DNA is synthesized via DNA replication enzymes.
Explain why cuts are made on both sites of the damaged region of the DNA in NER.
During NER cuts are made on both sites of the damaged region of the DNA so UvrD can remove the region.
What is the difference between BER and NER?
BER removes only the mismatched base, the backbone remains intact. NER removes a whole part of the DNA, including the backbone.
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