Gene mutation and DNA repair - Spontaneous mutations
10 important questions on Gene mutation and DNA repair - Spontaneous mutations
What are the two categories the causes of mutations are in?
- Spontaneous mutations;
- Induced mutations.
What are the three types of chemical changes that spontaneous mutations can arise?
- Depurination;
- Deamination;
- Tautomeric shift.
What is an apurinic site?
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When DNA replication occurs over an apurinic site, what is the probability that a mutation will occur?
Which of these two changes is more difficult for DNA repair enzymes to fix correctly? Explain why.
What is a tautomeric shift?
How does a tautomeric shift cause a mutation?
When a thymine has undergone a tautomeric shift, a guanine will bind to it instead of an adenine and the other way around.
When a cytosine has undergone a tautomeric shift, an adenine will bind to it instead of a guanine, and the other way around.
What happens to the DNA of the daughter cells when a thymine base has undergone a tautomeric shift prior to DNA replication?
What is oxidative DNA damage? And what causes it?
What is trinucleotide repeat expansion (TNRE)?
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