Non-mendelian inheritance - Epigenetic inheritance: genomic imprinting
7 important questions on Non-mendelian inheritance - Epigenetic inheritance: genomic imprinting
When does genomic imprinting happen?
What is monoallelic expression?
What would be the outcome of a cross between a heterozygous female and a homozygous male with two normal copies of the Igf2 gene?
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Explain why the erasure phase of imprinting is necessary in eggs.
What are the phases of genomic imprinting?
- The establishment of the imprint during gametogenesis;
- The maintenance of the imprint during embryogenesis and in adult somatic cells;
- The erasure and reestablishment of the imprint in the germ cells.
What is DNA methylation?
On the left side of this figure, explain why the offspring does not have Prader-Willi syndrome but does have Angelman syndrome.
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