Gene regulation in eukaryotes II: Epigenetics - Epigenetics and environmental agents
15 important questions on Gene regulation in eukaryotes II: Epigenetics - Epigenetics and environmental agents
Which two types of environmental agents that have effect on epigenetic modifications are recently studied a lot?
- Toxic agents.
What kind of gene in mice is studied a lot concerning the effect of diet on epigenetic changes?
What kind of genotypes in the Agouti gene cause what kind of phenotypes?
- Loss-of-function mutation (aa) causes black fur.
- Gain-of-function mutation causes overexpression of the Agouti gene, resulting in yellow fur (Avy).
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How is the Avy allele created on molecular level?
What is an intriguing observation in mice carrying the Avy allele?
Why can mice with the same genotype have such a variety in phenotype?
What environmental factor could affect epigenetic modifications?
How can diet have influence on DNA methylation?
How was the experiment of Waterland and Jirtle (2003) set up?
- They studied the differences in DNA methylation of the Avy allele in the offspring of those mice.
What did Waterland and Jirtle find?
Study of which types of animals also provides evidence that diet may affect DNa methylation?
What two types of female honeybees are there?
What are the differences between queen bees and worker bees?
How are the differences between queen bees and worker bees explained?
- The bees that become worker bees are fed pollen and nectar as well.
What molecular explanation is given for the influence of diet on the development of bees?
- These genes are methylated in worker bees.
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