Gene regulation in eukaryotes I: Transcriptional and translational regulation - Regulation of translation
7 important questions on Gene regulation in eukaryotes I: Transcriptional and translational regulation - Regulation of translation
How can mRNAs be regulated?
How is iron taken up into a cell (steps)?
- This transferrin-iron complex binds to a transferrin receptor on the surface of cells;
- The complex is transported into the cytosol by endocytosis;
- The iron is released into the cytosol;
- Two things can occur: the iron binds to enzymes that require iron, or the iron is stored within a hollow.
What mRNAs do iron regulatory proteins (IRPs) regulate?
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To what regulatory element within those two mRNAs does IRP bind?
When there is abundant iron in the cell, what happens to the ferritin mRNA?
What happens with the transferrin receptor mRNA when iron levels are low?
- The IRP/IRE complex prevents the degradation by endonucleases of the mRNA;
- Uptake of iron in the cell is therefore promoted.
What happens to the transferrin receptor mRNA when iron levels are high?
- IRP dissociates from transferrin receptor mRNA;
- Sites that are recognized by endonucleases in the mRNA are exposed when IRP dissociates;
- The mRNA is degraded, which leads to a decrease in the amount of transferrin receptor.
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