Gene regulation in eukaryotes I: Transcriptional and translational regulation - DNA methylation
13 important questions on Gene regulation in eukaryotes I: Transcriptional and translational regulation - DNA methylation
Via what enzyme occurs DNA methylation in eukaryotes?
To which base is the methyl group attached?
What are CpG islands?
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What is full methylation?
What are housekeeping genes?
How are the CpG island in housekeeping genes methylated?
What are tissue-specific genes?
What role does DNA methylation play in tissue-specific genes?
Where must the methylation occur in order to have an effect on transcription, and why?
What is an example of a protein that methyl-CpG-binding proteins recruit to the CpG island?
How is it possible that DNA methylation is heritable?
How is DNA methylation inherited (steps)?
- After DNA replication, one strand of the newly made DNA is methylated and the other is not (hemimethylated);
- Those DNA strands are fully methylated by DNA methyltransferase (this process is called maintenance methylation).
To what extent are de novo methylation and demethylation regulated?
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