Summary: Genome Regulation By Polycomb And Trithorax: 70 Years And Counting
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Read the summary and the most important questions on Genome Regulation by polycomb and trithorax: 70 years and counting
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34 Introduction
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Give two examples of evolutionary conserved chromatin modifying proteins
Polycomb (PcG) and Trithorax (TrxG) -
What were the polycomb and trithorax proteins are originally known for
As part of an epigenetic cellular memory system that maintains repressed or active gene expression states -
How do the polycomb group and trithorax group interact in gene cell differentiation and developmental processes?
Act antagonistically -
How did the definition of the Polycomb group proteins arise?
Mutations in polycomb proteins transformed anterior segments into more posterior ones due to abnormal /ectopic expression of Hox genes -
Mutations in the Trithorax gene (a regulator of Hox gene expression) lead to
Embryonic segments were transformed from posterior into anterior by antagonizing the PcG proteins -
PcG and TrxG members are linked to
Proliferation , senescence,cancer, X chromosome, inactivation, imprinting, cell cycle control, stem cell biology -
Since PcG and TrxG members is linked to cancer, cell cycle, imprinting, stem cell biology, then how?
There are a variety of PcG and Trx complexes that are assembled in a developmental stage and cell-specific manner to modify chromatin at their target genes via histone / chromatin ... -
Research has shown TrxG and PcG complexes can regulate at multiple levels...
From changing local chromatin structure, higher older chromatin organisation, global genome structure -
35 PcG 1
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PcG machinery has been subdivided into two main complexes
Polycomb repressive complex 1
Polycomb repressive complex 2 -
The Polycomb repressive complex 1 is much more diverse in mammals > Drosophila and this complex is subdivided into
Canonical cPCR1 and non canonical ncPRC1
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