PcG Complexes

9 important questions on PcG Complexes

What is the one thing all polycomb repressive complex 1 share in common, and found in all major animal lineages (excluding fungi)

A protein core

What is the PCR1 core made of?

The mammalian core is made of RING1A/B proteins and one of the 6 polycomb ring-finger domain protein (PCGF1-PCGF6)

Function of the RING proteins in the core of PCR1 complex

E3 ubiquitin ligase activity, it ubiquitinates histone 2A on lysine 119
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What else is found in the canonical subdivision of PRC1 complex?

A chromo box protein that binds H3K27me3 and a polyhomeotic protein. The polyhomeotic protein contains a sterile alpha motif (SAM) domain

The function of the sterile alpha domain (SAM) found in the canonical aspect of PCR1

Is essential for PcG-mediated repression

PcG proteins act to _______ transcription

REPRESS

As part of the canonical PRC1 subdivision, it is assembled around 2 ring finger domains

PCGF 2 /4

Describe the non-canonical domain of PRC1
It possesses...

Depending on the choice of PCGF protein it associates with, will determine the enzymatic activity of each complex

The nc PCR1 also includes proteins for

building a scaffold,
specific subunits can modulate their DNA binding affinity
demonstrate histone demethylase
and histone deacetylase

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