Microbioata in health and disease
3 important questions on Microbioata in health and disease
What are the 3 major phyla in the GI tract and what do they do?
Firmicutes (40-60%) Low G+C gram positieves - conversion of carbohydrates lactate and/or acetate into butyrateBacteriodetes (10-20%) Gram negative - degrade complex carbohydratesActinobacteria (10-15%) High G6C gram positive bacteria (bifidobacterium, a laction proudcing -> beneficial
Proteobacteria - Gram negative - sulfate reducing (but also lots of pathogenic
ecoli is most well known
Proteobacteria - Gram negative - sulfate reducing (but also lots of pathogenic
ecoli is most well known
How is IBS diagnosed?
3 days/mint in the last 3 moths associated with 2 or more of the following:
- improvement with defecation
- onset associated with a change in frequency of stool
- onset associated with a change in form of stool
Maybe linked to nterotypes instead of normal species
Hetrogenous
no longtime studies
What are the main SCFA (From converting carbohydrates) in feces?
Acetate, propionate and butyrate.
Also hartly detectable succinate and lactate
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