Endothelial Function - Introduction
3 important questions on Endothelial Function - Introduction
What are the three forms of NO producing enzymes and what do they do?
Nitrogen Oxide Synthase
- NOS-I
-Neuronal NOS / nNOS (Ca-dependent)
-neural tissue and the skeletal muscle - NOS-II / iNOS
-Inducible NOS
-Immune system>macrophages - NOS-III /eNOS/cNOS
-Endothelial NOS (Ca-dependent, activated by shear forces)
How does prostacyclin work?
Via Gs-prtein pathway. It stimulates AC (Adenyl cyclase_ which catalyzes the formation of cAMP. This reduces contraction by imhibiting MLCK *myosin light chin kinase)
How does EDHF work?
EDHF is an electrical phenomenon in which an initial endothelial hyperpolarization spreads to the
vascular smooth muscle via a myoendothelial gap junction, closing L-type voltage-gated Ca channels, reducing Ca2+ and thus vasorelaxation.
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