Disorders of Neurohypophysis - Vasopressin - Synthesis and Secretion

7 important questions on Disorders of Neurohypophysis - Vasopressin - Synthesis and Secretion

Which copeptide is packaged with vasopressin?

Neurophysis II

Do the osmoreceptors in the hypothalamus react to osmotic pressure changes caused by glucose?

no

What is the role of the baroregulatory system in the regulation of the vasopressin release threshold?

They can lower the threshold when bloodpressure shows an acute fall of >10%.
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What happens when your ADH levels fall?

  • Volume of body fluids increases
  • Osmolarity decreases

How does the kidney work?

  • filtration by glomunerus
  • reabsorption of solutions in first duct
  • reabsorption of water in Henle's Loop
  • reabsorption of water in the end ducts by ADH

How does the reabsorption of water by ADH work?

  • ADH attaches at VA2-receptors which has G-coupledprotein
  • G-couppled protein activates c-AMP
  • c-AMP activates aquaporin
  • The ducts become more permeable

Why does a pregnant woman has a lowered threshold for ADH production?

This is because of the catabolic effect of placenta enzymes on ADH.

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