Hypothalamic and anterior pituitary insufficiency - Developmental and genetic causes of hypopituitarism - Tissue-specific factor mutations

4 important questions on Hypothalamic and anterior pituitary insufficiency - Developmental and genetic causes of hypopituitarism - Tissue-specific factor mutations

Which two transcription factors are critical to the development of the anterior pituitary?

  • Pit-1
  • Prop-1

What is the function of the two critical transcription factors associated with the development of the anterior pituitary?

They determine the development of differentiated anterior pituitary cells.

How can a tissue-specific mutation in the anterior pituitary be shown on a MRI-scan?

By showing signs of hypoplasma
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Which anterior pituitary hormones are reduced by a dysfunction in the Prop-1 transcription factor?

  • GH
  • TSH
  • gonadotrophins
  • PRL

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