Disorders of Anterior Pituitary and Hypothalamus - Hypothalamic and anterior pituitary insufficiency - Acquired Hypopituitarism

5 important questions on Disorders of Anterior Pituitary and Hypothalamus - Hypothalamic and anterior pituitary insufficiency - Acquired Hypopituitarism

What are the major causes of acquired Hypopituitarism?

  • Hypothalamic infiltration disorders
  • Inflammatory Lesions
  • Lymphocytic hypophysitis
  • Pituitary apoplexy
  • Empty sella
  • Cranial Irradiation

How can TBI cause hypopituitarism?

Following TBI the cranial nerves can be damaged and oedema around the skullbase can cause pressure of the pituitary.

What are the most common infections associated with acquired hypopituitarism?

  • Tuberculosis
  • fungal infections
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Which part of the hypothalamic-pituitary axis suffers the most from cranial irradiation?

The hypothalamic nuclei

The dysfunction of which pituitary hormone is most common in cranial irradiation?

GH deficienies

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