Deficiencies of Vasopressin secretion and action - Diabetes Insipidus - Differential diagnosis

5 important questions on Deficiencies of Vasopressin secretion and action - Diabetes Insipidus - Differential diagnosis

What are the clinicial symptoms of DI?

  • nocturia
  • enuresis
  • persistent thirst
  • polyuria

How is DI evaluated?

  • By taking a 24h urine sample comparing to the fluid intake
  • for subcategorial diagnosis you can do a fluid restriction test, if AVP is high you've got nephrogenic polydipsia, if AVP is low you've got pituitary DI
  • MRI of the hypothalamus/pituitary

How does desmopressin work?

It works analogues to vasopressin, though more gradually
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On which type of DI does desmopressin work?

On Pituitary DI as it is an AVP agonist.

How is primary polydipsia characterized on a MRI scan?

By a bright spot in the hypophysis

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