Hypothalamic, Pituitary, and other sellar masses - Pituitary tumors - Pathogenesis
3 important questions on Hypothalamic, Pituitary, and other sellar masses - Pituitary tumors - Pathogenesis
How are hormonal active tumors characterized?
- reduced responsiveness to feedback mechanisms
- increased autonomous hormonal production
What seems to be the biochemical cause of GH tumor GH overproduction?
By mutations in the genes attenuating GTPase activity which increases the plasma level op AMP which increases the secretion of GH.
Does each hormone producing cell in the anterior pituitary have a different tumorname?
They do:
- Lactotrophic (PRL)
- Somatothropic (GH)
- Gonadotrophic (LH/FSH)
- Corticothropic (ACTH)
- Thyrothropic (TSH)
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