Deficiencies of Vasopressin secretion and action - Adisipic Hypernatremia - Differential diagnosis

4 important questions on Deficiencies of Vasopressin secretion and action - Adisipic Hypernatremia - Differential diagnosis

What is the difference between the syndrome of inappropriate antidiuresis and adisipic hypernatremia?

Both diseases have a defect in the osmoregulation by AVP. However, in adisipic hypernatremia AVP is produced but at such a low level that urine concentrations keeps increasing. On the other hand in SIAD the release of AVP fluctuates uncontrolled indicating a loss in regulation.

What are the diagnostic criteria for adipisic hypernatremia?

  • denial of thirst
  • refusal to drink spontaneously
  • hypernatremia

What is your advise regarding adisipic hypernatremia?

Monitoring hypotonic fluid intake until plasma concentrations become normal and stable.
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What should you do when you find somebody with a complete deficiency in Adipsic hypernatremia?

You should rehydrate the person while monitoring.

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